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KMID : 0043319870100010029
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Archives of Pharmacal Research
1987 Volume.10 No. 1 p.29 ~ p.35
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Studies on the Interaction of Edible Dyes with Protein (II). The effects of drug additions on protein binding of edible dyes
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Kim BK
Lah WL/Jang SK/Lim BH/Jang JY/Lee WK
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Abstract
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The effect of drug addition on the bovine serum albumin (BSA)-edible dye complex was studied by spectrophotometric method. The edible dyes tested were amaranth, erythrosine, tatrazine and sunset yellow. The moles of bound dye per protein mole and free energies for edible dyes bounded were determined at pH 7.4. The values of free energy change by the addition of drugs to BSA-edible dye were ranged from -6,260 to -8,030cal/mole. In the wide range of edible dye concentration (0. 3-7 X 10-5 M), acetylsalicylic acid(ASA) showed pattern of displacement different from that of dye. It was assumed that ASA has different binding mechanisms from edible dye.
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